Metastasis is a crucial hallmark of cancer progression, which involves numerous factors
including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase
(JAK)/STAT signalling cascade and is best known for its essential role in mediating …

Tumor-associated inflammation is predictive of poor prognosis and drives a variety of
tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

Epithelial-to-mesenchymal transition (EMT), a crucial developmental program, contributes to
cancer invasion and metastasis. In this study, we show that death-effector domain …

Gastrointestinal (GI) malignancies are the most prevalent tumors worldwide, with increasing
incidence and mortality. Although surgical resection, chemotherapy, radiotherapy, and …

Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. They are
traditionally considered to be cholesterol-lowering agents, but in recent years more and …

Background Kidney renal clear cell carcinoma (KIRC) is the most frequently diagnosed
subtype of renal cell carcinoma (RCC); however, the pathogenesis and diagnostic …

Hepatocellular carcinoma (HCC) is a complication at the endstage of chronic inflammatory
liver diseases with dismal prognosis. Targeting of Toll‐like receptor (TLR) 2 attenuates …