The gut microbiome in Alzheimer's disease: what we know and what remains to be explored

S Chandra, SS Sisodia, RJ Vassar - Molecular neurodegeneration, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

The microbiota–gut–brain Axis in psychiatric disorders

A Góralczyk-Bińkowska, D Szmajda-Krygier… - International journal of …, 2022 - mdpi.com
Modulating the gut microbiome and its influence on human health is the subject of intense
research. The gut microbiota could be associated not only with gastroenterological diseases …

Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia

LJ Dominguez, N Veronese, L Vernuccio, G Catanese… - Nutrients, 2021 - mdpi.com
Multiple factors combined are currently recognized as contributors to cognitive decline. The
main independent risk factor for cognitive impairment and dementia is advanced age …

Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis

T Ashleigh, RH Swerdlow, MF Beal - Alzheimer's & Dementia, 2023 - Wiley Online Library
To promote new thinking of the pathogenesis of Alzheimer's disease (AD), we examine the
central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by …

The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

A Chakrabarti, L Geurts, L Hoyles, P Iozzo… - Cellular and Molecular …, 2022 - Springer
The gut and brain link via various metabolic and signalling pathways, each with the potential
to influence mental, brain and cognitive health. Over the past decade, the involvement of the …

Neurodegenerative and neurodevelopmental diseases and the gut-brain axis: The potential of therapeutic targeting of the microbiome

B Bicknell, A Liebert, T Borody, G Herkes… - International journal of …, 2023 - mdpi.com
The human gut microbiome contains the largest number of bacteria in the body and has the
potential to greatly influence metabolism, not only locally but also systemically. There is an …

The role of diet as a modulator of the inflammatory process in the neurological diseases

A Kurowska, W Ziemichód, M Herbet… - Nutrients, 2023 - mdpi.com
Neurological diseases are recognized as major causes of disability and mortality worldwide.
Due to the dynamic progress of diseases such as Alzheimer's disease (AD), Parkinson's …

Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …