Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate
and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which …

Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Abstract Glypican-3 (GPC3) is a cell surface heparan sulfate proteoglycan that is being
evaluated as an emerging therapeutic target in hepatocellular carcinoma (HCC). GPC3 has …

Oral squamous cell carcinoma (OSCC) accounts for around 90% of all oral cancers and is
the eighth most common cancer worldwide. Despite progress in managing OSCC, the …

Objective: Gallbladder cancer (GBC) mortality remains high and chemoresistance is
increasing. This review consolidates what is known about the mechanisms of …

Vascular smooth muscle cells (VSMCs) are normally quiescent and non-migratory,
regulating the contraction and relaxation of blood vessels to control the vascular tone. In …

Objective Previous studies have revealed that FAT atypical cadherin 1 (FAT1) plays a tumor-
suppressive or oncogenic role in a context-dependent manner in various cancers. However …

Head and neck cancers are highly prevalent worldwide. Most of these lesions are
diagnosed in the advanced stages of the disease. Thus, they do not often have a good long …

Aims and hypothesis Epidermal growth factor (EGF) has been shown to induce the migration
of various cancer cells. However, the underlying signaling mechanisms for EGF-induced …