Traditional Chinese medicine (TCM) has a long history of viewing an individual or patient as
a system with different statuses, and has accumulated numerous herbal formulae. The …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Abstract Systems pharmacology is an emerging field that integrates systems biology and
pharmacology to advance the process of drug discovery, development and the …

The scientific understanding of traditional Chinese medicine (TCM) has been hindered by
the lack of methods that can explore the complex nature and combinatorial rules of herbal …

Ethnopharmacological relevance Alzheimer's disease (AD), as the most common type of
dementia, has brought a heavy economic burden to healthcare system around the world …

The concept of “network target” has ushered in a new era in the field of traditional Chinese
medicine (TCM). As a new research approach, network pharmacology is based on the …

Network-based intervention has been a trend of curing systemic diseases, but it relies on
regimen optimization and valid multi-target actions of the drugs. The complex multi …

Alzheimer's Disease (AD) is a neurodegenerative condition that currently has no known
cure. The principles of the expanding field of network medicine (NM) have recently been …

Cardiovascular diseases (CVDs) have been regarding as “the world's first killer” of human
beings in recent years owing to the striking morbidity and mortality, the involved molecular …

G protein-coupled receptors (GPCRs), widely expressed in the human central nervous
system (CNS), perform numerous physiological functions and play a significant role in the …