The intestinal epithelium is a rapidly renewing cellular compartment. This constant
regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance …

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …

The Notch signalling pathway mediates cell fate decisions, and is tumour suppressive or
oncogenic depending on the context,. During lung development, Notch pathway activation …

Mouse heart development arises from Mesp1-expressing cardiovascular progenitors (CPs)
that are specified during gastrulation. The molecular processes that control early regional …

Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of
embryonic development and it is involved in homeostasis of adult tissues. In the …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Basal cells (BCs) are p63-expressing multipotent progenitors of skin, tracheoesophageal
and urinary tracts. p63 is abundant in developing airways; however, it remains largely …

Notch signaling has been shown over the past few decades to play fundamental roles in a
plethora of developmental processes in an evolutionarily conserved fashion. Notch …

Epicardial cells on the heart's surface give rise to coronary artery smooth muscle cells
(caSMCs) located deep in the myocardium. However, the differentiation steps between …

Renewal of the intestinal epithelium occurs approximately every week and requires a careful
balance between cell proliferation and differentiation to maintain proper lineage ratios and …