The updated landscape of tumor microenvironment and drug repurposing
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
Cyclooxygenase‐2 in cancer: a review
Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …
[HTML][HTML] Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer
H Chen, Q Qi, N Wu, Y Wang, Q Feng, R Jin, L Jiang - Redox Biology, 2022 - Elsevier
Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation
of phospholipids, is associated with cellular metabolism, redox homeostasis, and various …
of phospholipids, is associated with cellular metabolism, redox homeostasis, and various …
[HTML][HTML] Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications
Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …
whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was …
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions
Y Li, X He, X Lu, Z Gong, Q Li, L Zhang, R Yang… - Nature …, 2022 - nature.com
Abstract The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear
protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 …
protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 …
FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway
ZH He, M Li, QJ Fang, FL Liao, SY Zou, X Wu, HY Sun… - Autophagy, 2021 - Taylor & Francis
Presbycusis is the cumulative effect of aging on hearing. Recent studies have shown that
common mitochondrial gene deletions are closely related to deafness caused by …
common mitochondrial gene deletions are closely related to deafness caused by …
Drug repurposing in cancer therapy: influence of patient's genetic background in breast cancer treatment
Cancer is among the leading causes of death worldwide and it is estimated that in 2040
more than 29 million people will be diagnosed with some type of cancer. The most prevalent …
more than 29 million people will be diagnosed with some type of cancer. The most prevalent …
[HTML][HTML] Metabolic fingerprinting links oncogenic PIK3CA with enhanced arachidonic acid-derived eicosanoids
Oncogenic transformation is associated with profound changes in cellular metabolism, but
whether tracking these can improve disease stratification or influence therapy decision …
whether tracking these can improve disease stratification or influence therapy decision …
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT‐3 signalling pathway
Y Wang, G He, H Tang, Y Shi, X Kang, J Lyu… - Cell …, 2019 - Wiley Online Library
Objectively Tendinopathy is a common problem in sports medicine which can lead to severe
morbidity. Aspirin, as the classical representative of non‐steroidal anti‐inflammatory drugs …
morbidity. Aspirin, as the classical representative of non‐steroidal anti‐inflammatory drugs …
Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against
Aspirin as a possible treatment of cancer has been of increasing interest for over 50 years,
but the balance of the risks and benefits remains a point of contention. We summarise the …
but the balance of the risks and benefits remains a point of contention. We summarise the …