Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that orchestrates a diverse
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions of
people worldwide. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are …

Inhibition of leucine-rich repeat kinase 2 is a genetically supported mechanism for the
treatment of Parkinson's disease. We previously disclosed the discovery of an indazole …

The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally
linked to Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder …

Inhibition of leucine-rich repeat kinase 2 (LRRK2) kinase activity represents a genetically
supported, chemically tractable, and potentially disease-modifying mechanism to treat …

Inhibitors of leucine-rich repeat kinase 2 (LRRK2) and mutants, such as G2019S, have
potential utility in Parkinson's disease treatment. Fragment hit-derived pyrrolo [2, 3-d] …

Genetic mutation of the leucine-rich repeat kinase 2 (LRRK2) protein has been associated
with Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder that …

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Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) is a potential target for
Parkinson's disease therapy. In this work, the computational evaluation of the LRRK2 …

Parkinson's disease (PD) is a common neurodegenerative disease affecting nearly 10
million people worldwide and placing a heavy medical burden on both society and families …