Diverse RNA viruses of parasitic nematodes can elicit antibody responses in vertebrate hosts

S Quek, A Hadermann, Y Wu, L De Coninck… - Nature …, 2024 - nature.com
Parasitic nematodes have an intimate, chronic and lifelong exposure to vertebrate tissues.
Here we mined 41 published parasitic nematode transcriptomes from vertebrate hosts and …

Genetic and functional diversification of chemosensory pathway receptors in mosquito-borne filarial nematodes

NJ Wheeler, ZW Heimark, PM Airs, A Mann… - PLoS …, 2020 - journals.plos.org
Lymphatic filariasis (LF) afflicts over 60 million people worldwide and leads to severe
pathological outcomes in chronic cases. The nematode parasites (Nematoda: Filarioidea) …

Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi

PM Airs, K Vaccaro, KJ Gallo, N Dinguirard… - PLoS …, 2022 - journals.plos.org
Lymphatic filariasis (LF) is a chronic debilitating neglected tropical disease (NTD) caused by
mosquito-transmitted nematodes that afflicts over 60 million people. Control of LF relies on …

Improved metagenome assemblies through selective enrichment of bacterial genomic DNA from eukaryotic host genomic DNA using ATAC-seq

LJ Cantin, JC Dunning Hotopp, JM Foster - Frontiers in Microbiology, 2024 - frontiersin.org
Genomics can be used to study the complex relationships between hosts and their
microbiota. Many bacteria cannot be cultured in the laboratory, making it difficult to obtain …

Updated annotation and meta-analysis of Brugia malayi transcriptomics data reveals consistent transcriptional profiles across time and space with some study …

CI Holt, JC Dunning Hotopp - PLOS Neglected Tropical Diseases, 2024 - journals.plos.org
Genomics, transcriptomics, and proteomics have significantly advanced our understanding
of obligately host-associated microbes, where interrogation of the biology is often limited by …

Long-read RNA sequencing of human and animal filarial parasites improves gene models and discovers operons

NJ Wheeler, PM Airs, M Zamanian - PLoS Neglected Tropical …, 2020 - journals.plos.org
Filarial parasitic nematodes (Filarioidea) cause substantial disease burden to humans and
animals around the world. Recently there has been a coordinated global effort to generate …

Defining the filarial N-glycoproteome by glycosite mapping in the human parasitic nematode Brugia malayi

FB Mersha, CM McClung, M Chen, CI Ruse… - Scientific Reports, 2023 - nature.com
N-linked glycosylation is a critical post translational modification of eukaryotic proteins. N-
linked glycans are present on surface and secreted filarial proteins that play a role in host …

Drug repurposing of bromodomain inhibitors as potential novel therapeutic leads for lymphatic filariasis guided by multispecies transcriptomics

M Chung, LE Teigen, S Libro, RE Bromley, D Olley… - Msystems, 2019 - Am Soc Microbiol
To better understand the transcriptomic interplay of organisms associated with lymphatic
filariasis, we conducted multispecies transcriptome sequencing (RNA-Seq) on the filarial …

SMC-mediated dosage compensation in C. elegans evolved in the presence of an ancestral nematode mechanism

A Aharonoff, J Kim, A Washington, S Ercan - bioRxiv, 2024 - biorxiv.org
Mechanisms of X chromosome dosage compensation have been studied extensively in a
few model species representing clades of shared sex chromosome ancestry. However, the …

[PDF][PDF] The RNA virome of human and animal parasitic nematodes

S Quek, A Hadermann, Y Wu… - Research …, 2023 - assets-eu.researchsquare.com
Screening published transcriptomes, we have discovered 75 RNA viruses that infect 27
species of parasitic nematodes, responsible for> 1.5 billion infections in people and animals …