Lymphatic filariasis (LF) afflicts over 60 million people worldwide and leads to severe pathological outcomes in chronic cases. The nematode parasites (Nematoda: Filarioidea) …
Lymphatic filariasis (LF) is a chronic debilitating neglected tropical disease (NTD) caused by mosquito-transmitted nematodes that afflicts over 60 million people. Control of LF relies on …
LJ Cantin, JC Dunning Hotopp, JM Foster - Frontiers in Microbiology, 2024 - frontiersin.org
Genomics can be used to study the complex relationships between hosts and their microbiota. Many bacteria cannot be cultured in the laboratory, making it difficult to obtain …
Genomics, transcriptomics, and proteomics have significantly advanced our understanding of obligately host-associated microbes, where interrogation of the biology is often limited by …
Filarial parasitic nematodes (Filarioidea) cause substantial disease burden to humans and animals around the world. Recently there has been a coordinated global effort to generate …
FB Mersha, CM McClung, M Chen, CI Ruse… - Scientific Reports, 2023 - nature.com
N-linked glycosylation is a critical post translational modification of eukaryotic proteins. N- linked glycans are present on surface and secreted filarial proteins that play a role in host …
To better understand the transcriptomic interplay of organisms associated with lymphatic filariasis, we conducted multispecies transcriptome sequencing (RNA-Seq) on the filarial …
A Aharonoff, J Kim, A Washington, S Ercan - bioRxiv, 2024 - biorxiv.org
Mechanisms of X chromosome dosage compensation have been studied extensively in a few model species representing clades of shared sex chromosome ancestry. However, the …
S Quek, A Hadermann, Y Wu… - Research …, 2023 - assets-eu.researchsquare.com
Screening published transcriptomes, we have discovered 75 RNA viruses that infect 27 species of parasitic nematodes, responsible for> 1.5 billion infections in people and animals …