[HTML][HTML] Bioactive flavonoids in medicinal plants: Structure, activity and biological fate

T Wang, Q Li, K Bi - Asian journal of pharmaceutical sciences, 2018 - Elsevier
Flavonoids, a class of polyphenol secondary metabolites, are presented broadly in plants
and diets. They are believed to have various bioactive effects including anti-viral, anti …

Flavones: An important scaffold for medicinal chemistry

M Singh, M Kaur, O Silakari - European journal of medicinal chemistry, 2014 - Elsevier
Flavones have antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl
cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular …

Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice

S Fan, Y Zhang, Q Sun, L Yu, M Li, B Zheng… - The Journal of nutritional …, 2014 - Elsevier
Okra is an important tropical vegetable and source of dietary medicine. Here, we assayed
the effects of an ethanol extract of okra (EO) and its major flavonoids isoquercitrin and …

Cancer biology and prevention in diabetes

SP Srivastava, JE Goodwin - Cells, 2020 - mdpi.com
The available evidence suggests a complex relationship between diabetes and cancer.
Epidemiological data suggest a positive correlation, however, in certain types of cancer, a …

Animal models of diabetes mellitus for islet transplantation

N Sakata, G Yoshimatsu, H Tsuchiya… - Journal of Diabetes …, 2012 - Wiley Online Library
Due to current improvements in techniques for islet isolation and transplantation and
protocols for immunosuppressants, islet transplantation has become an effective treatment …

Interactions among long non-coding RNAs and microRNAs influence disease phenotype in diabetes and diabetic kidney disease

SP Srivastava, JE Goodwin, P Tripathi… - International Journal of …, 2021 - mdpi.com
Large-scale RNA sequencing and genome-wide profiling data revealed the identification of
a heterogeneous group of noncoding RNAs, known as long noncoding RNAs (lncRNAs) …

Discovery and anti-diabetic effects of novel isoxazole based flavonoid derivatives

JP Nie, ZN Qu, Y Chen, JH Chen, Y Jiang, MN Jin… - Fitoterapia, 2020 - Elsevier
O-[(E)-4-(4-cyanophenyl)-2-oxobut-3-en-1-yl] kaempferol is a novel lead compound to
discover anti-diabetic and anti-obesity drugs. The present study reported the scaffold …

Loss of mitochondrial control impacts renal health

SP Srivastava, K Kanasaki, JE Goodwin - Frontiers in Pharmacology, 2020 - frontiersin.org
Disruption of mitochondrial biosynthesis or dynamics, or loss of control over mitochondrial
regulation leads to a significant alteration in fuel preference and metabolic shifts that …

Coronavirus disease (COVID)-19 and diabetic kidney disease

SP Srivastava, R Srivastava, S Chand, JE Goodwin - Pharmaceuticals, 2021 - mdpi.com
The present review describes COVID-19 severity in diabetes and diabetic kidney disease.
We discuss the crucial effect of COVID-19-associated cytokine storm and linked injuries and …

Antidiabetic Activities of Hydromethanolic Leaf Extract of Calpurnia aurea (Ait.) Benth. Subspecies aurea (Fabaceae) in Mice

YM Belayneh, EM Birru - Evidence‐Based Complementary and …, 2018 - Wiley Online Library
Diabetes mellitus is one of the largest global health problems demanding preventive and
new therapeutic interventions. Currently, there is a need for safe, effective, and less costly …