Tissue regenerative medicine combines the use of cells, scaffolds, and molecules to repair
damaged tissues. Different cell types are employed for musculoskeletal diseases, both …

OBJECTIVE: The etiology of Condylar hyperplasia (CH) of human temporomandibular joint
(TMJ) remains largely unknown. Our previous study has demonstrated that enriched insulin …

Legislative requirements for the quality of pharmacological agents underwent certain
evolution when new type of therapies emerged. This relates to cell based medicines, such …

Introduction Signals from the epidermal growth factor receptor (EGFR) have typically been
considered to provide catabolic activities in articular cartilage, and accordingly have been …

The occurrence of type 2 diabetes (T2D) increases with age. The platelet-derived growth
factor (PDGF) is one of the key factors regulating β cell proliferation and function, but the …

The management of chondral defects has long been a challenge because of the poor self-
healing capacity of articular cartilage. Many approaches ranging from symptomatic treatment …

Study Design. We hypothesized that AF/neuron interactions during annular injury were
involved in neovascularization and nerve ingrowth, the pathologic hallmarks of symptomatic …

To identify the effects of running on articular cartilage and subchondral bone remodeling,
C57BL/6 mice were randomly divided into three groups: control, moderate‐, and strenuous …

Objectives Physiological oxygen tension plays a critical role in homoeostatic maintenance
and development of endochondral bone. Based on the proximity between uncalcified …

骨关节炎是一种累及整个关节的慢性退行性疾病， 它的发生、 发展与软骨、 软骨下骨、
滑膜等组织的破坏及代谢异常存在密切关系。 血小板衍生生长因子-AA（ PDGF-AA） …