The making of the Drosophila mushroom body

S Lin - Frontiers in Physiology, 2023 - frontiersin.org
The mushroom body (MB) is a computational center in the Drosophila brain. The intricate
neural circuits of the mushroom body enable it to store associative memories and process …

Genetics and genomics of alcohol responses in Drosophila

A Park, A Ghezzi, TP Wijesekera, NS Atkinson - Neuropharmacology, 2017 - Elsevier
Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

[HTML][HTML] Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326

J Ke, Y Yao, J Zheng, P Wang, Y Liu, J Ma, Z Li, X Liu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Glioma is the most common and aggressive primary adult brain tumor. Long non-coding
RNAs (lncRNAs) have important roles in a variety of biological properties of cancers. Here …

Flying Together: Drosophila as a Tool to Understand the Genetics of Human Alcoholism

DR Lathen, CB Merrill, A Rothenfluh - International journal of molecular …, 2020 - mdpi.com
Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

The genetic basis of natural variation in mushroom body size in Drosophila melanogaster

L Zwarts, L Vanden Broeck, E Cappuyns… - Nature …, 2015 - nature.com
Genetic variation in brain size may provide the basis for the evolution of the brain and
complex behaviours. The genetic substrate and the selective pressures acting on brain size …

Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder

M Grotewiel, JC Bettinger - Alcoholism: Clinical and …, 2015 - Wiley Online Library
Background Despite the profound clinical significance and strong heritability of alcohol use
disorder (AUD), we do not yet have a comprehensive understanding of the naturally …

Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders

S Byeon, S Yadav - Science Signaling, 2024 - science.org
Thousand and one amino acid kinases (TAOKs) are relatively understudied and functionally
pleiotropic protein kinases that have emerged as important regulators of neurodevelopment …

Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'

GL Engel, K Taber, E Vinton, AJ Crocker - Behavioral and Brain Functions, 2019 - Springer
Our understanding of the networks of genes and protein functions involved in Alcohol Use
Disorder (AUD) remains incomplete, as do the mechanisms by which these networks lead to …

Testing implications of the omnigenic model for the genetic analysis of loci identified through genome-wide association

W Zhang, GR Reeves, D Tautz - Current Biology, 2021 - cell.com
Organismal phenotypes usually have a quantitative distribution, and their genetic
architecture can be studied by genome-wide association (GWA) mapping approaches. In …

Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila

AK De Nobrega, LC Lyons - Journal of biological rhythms, 2016 - journals.sagepub.com
Delineating the factors that affect behavioral and neurological responses to alcohol is critical
to facilitate measures for preventing or treating alcohol abuse. The high degree of conserved …