It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …

Genome‐wide association, the latest gene‐finding strategy, has led to the first major
success in the field of obesity genetics with the discovery of FTO (fat mass and obesity …

Background Variation in the fat mass and obesity–associated (FTO) gene has provided the
most robust associations with common obesity to date. However, the role of FTO variants in …

Human FTO gene variants are associated with body mass index and type 2 diabetes.
Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO …

OBJECTIVE—Common variation in the FTO gene is associated with BMI and type 2
diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin …

Two recent, large whole-genome association studies (GWAS) in European populations have
associated a∼ 47-kb region that contains part of the FTO gene with high body mass index …

Background The fat mass and obesity–associated gene (FTO) has been shown to be
associated with obesity and to influence appetite regulation. Objective The aim was to …

FTO (fat mass and obesity associated) was identified as an obesity-susceptibility gene by
several independent large-scale genome association studies. A cluster of SNPs (single …

Background The pathogenesis of obesity is reportedly related to variations in the fat mass
and an obesity-associated gene (FTO); however, as the number of reports increases …

OBJECTIVE—Genetic variants in the fat mass and obesity-associated (FTO) gene have
been linked with obesity and type 2 diabetes in European populations. We aimed to test the …