Design, synthesis, characterization, and biological evaluation of novel pyrazine-1, 3, 4-oxadiazole/[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine hybrids as potent …
P Dinesha, D Udayakumar, VP Shetty… - Journal of Molecular …, 2024 - Elsevier
In this study, we present novel pyrazine-1, 3, 4-oxadiazole hybrids (T1-T9) and [1, 2, 4]
triazolo [3, 4-b][1, 3, 4] thiadiazine derivatives (T10-T18), which possess remarkable …
triazolo [3, 4-b][1, 3, 4] thiadiazine derivatives (T10-T18), which possess remarkable …
Synthesis, computational and UV–Vis absorption studies of novel sulfathiazole azo sulfonamides acting as potent antitubercular agents
In this work, we have reported the synthesis of unprecedented sulfonamide azo dyes 4 (aj)
by the diazo-coupling reaction of sulfathiazole with various coupling components. Different …
by the diazo-coupling reaction of sulfathiazole with various coupling components. Different …
Noncovalent inhibitors of DprE1 for tuberculosis treatment: design, synthesis, characterization, in vitro and in silico studies of 4-oxo-1,4-dihydroquinazolinylpyrazine …
Shivakumar, P Dinesha… - Journal of Biomolecular …, 2024 - Taylor & Francis
In this study, we present a novel series of 4-oxo-1, 4-dihydroquinazolinylpyrazine-2-
carboxamide derivatives, which exert their inhibitory effect on decaprenylphosphoryl-β-D …
carboxamide derivatives, which exert their inhibitory effect on decaprenylphosphoryl-β-D …
Structure-based drug design and characterization of novel pyrazine hydrazinylidene derivatives with a benzenesulfonate scaffold as noncovalent inhibitors of DprE1 …
Shivakumar, P Dinesha, D Udayakumar - Molecular Diversity, 2024 - Springer
In this study, we present a novel series of (E)-4-((2-(pyrazine-2-carbonyl) hydrazineylidene)
methyl) phenyl benzenesulfonate (T1-T8) and 4-((E)-(((Z)-amino (pyrazin-2-yl) methylene) …
methyl) phenyl benzenesulfonate (T1-T8) and 4-((E)-(((Z)-amino (pyrazin-2-yl) methylene) …
Synthesis and In vitro Screening of Pyrazine-2-Carbohydrazide Derivatives as Potential Antimicrobial Agents
P Dinesha, D Udayakumar, VP Shetty… - Journal of …, 2024 - ui.adsabs.harvard.edu
Herein, we report the design of a new set of pyrazine-2-carbohydrazide derivatives (T1-T20)
and in silico investigations to evaluate their inhibition activity against the enzyme …
and in silico investigations to evaluate their inhibition activity against the enzyme …
Synthesis and biological evaluation of novel hybrid compounds bearing pyrazine and 1, 2, 4-triazole analogues as potent antitubercular agents
S Naik, D Puttachari, AL Vanishree… - RSC …, 2024 - pubs.rsc.org
In this study, we elucidate the conceptualization and synthesis of hybrid compounds (T1–
T18) amalgamating pyrazine and 1, 2, 4-triazole scaffolds. A total of eighteen compounds …
T18) amalgamating pyrazine and 1, 2, 4-triazole scaffolds. A total of eighteen compounds …