Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Recent developments in catalytic asymmetric inverse-electron-demand Diels–Alder reaction

X Jiang, R Wang - Chemical Reviews, 2013 - ACS Publications
In general, DA reactions can be classified into two types of suprafacial [π4s+ π2s]
cycloadditions:(i) the normal and (ii) inverse-electron-demand DA reactions (Scheme 1) …

Applications of asymmetric organocatalysis in medicinal chemistry

J Alemán, S Cabrera - Chemical Society Reviews, 2013 - pubs.rsc.org
In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts,
has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched …

Advances in rosin-based chemicals: the latest recipes, applications and future trends

S Kugler, P Ossowicz, K Malarczyk-Matusiak… - Molecules, 2019 - mdpi.com
A comprehensive review of the publications about rosin-based chemicals has been
compiled. Rosin, or colophony, is a natural, abundant, cheap and non-toxic raw material …

Catalytic asymmetric chemoselective 1, 3-dipolar cycloadditions of an azomethine ylide with isatin-derived imines: diastereo-and enantioselective construction of a …

YM Wang, HH Zhang, C Li, T Fan, F Shi - Chemical Communications, 2016 - pubs.rsc.org
A catalytic asymmetric chemoselective 1, 3-dipolar cycloaddition (1, 3-DC) of an azomethine
ylide with imines has been established via a three-component reaction of isatin-derived …

Chiral thioureas—preparation and significance in asymmetric synthesis and medicinal chemistry

F Steppeler, D Iwan, E Wojaczyńska, J Wojaczyński - Molecules, 2020 - mdpi.com
For almost 20 years, thioureas have been experiencing a renaissance of interest with the
emerged development of asymmetric organocatalysts. Due to their relatively high acidity and …

Core scaffold‐inspired concise synthesis of chiral spirooxindole‐pyranopyrimidines with broad‐spectrum anticancer potency

X Jiang, Y Sun, J Yao, Y Cao, M Kai… - Advanced Synthesis …, 2012 - Wiley Online Library
Due to the lack of tumor‐specific anticancer agents, the discovery and development of new
types of highly selective anticancer agents is still a very urgent topic. Herein, we present our …

Recent Advances of α‐Isothiocyanato Compounds in the Catalytic Asymmetric Reaction

WY Han, JQ Zhao, J Zuo, XY Xu… - Advanced Synthesis …, 2015 - Wiley Online Library
Abstract α‐Isothiocyanato amides, esters and phosphonates have emerged as new types of
versatile reagents for various organo‐and metal‐catalyzed asymmetric cascade reactions …

Catalytic asymmetric β, γ activation of α, β-unsaturated γ-butyrolactams: direct approach to β, γ-functionalized dihydropyranopyrrolidin-2-ones.

X Jiang, L Liu, P Zhang, Y Zhong… - Angewandte …, 2013 - search.ebscohost.com
The divergence of natural products resulting from evolution provides organic chemists with a
prodigious starting point to design and construct a diverse array of bioactive compounds …

Terpene‐Derived Bifunctional Thioureas in Asymmetric Organocatalysis

S Narayanaperumal, DG Rivera, RC Silva… - …, 2013 - Wiley Online Library
Chiral hydrogen‐bond donors have played a crucial role in the progress of asymmetric
catalysis as an essential tool in modern organic synthesis. Among these donors, thioureas …