Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

Activity-dependent changes in the strength of synaptic connections are fundamental to the
formation and maintenance of memory. The mechanisms underlying persistent changes in …

The immediate early gene Arc is emerging as a versatile, finely tuned system capable of
coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing …

Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-
kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the …

Synaptic plasticity, the fundamental ability of synapses to undergo experience-dependent
changes in synaptic strength, is thought to underlie a range of long-term adaptive responses …

Translational control in neurons is crucially required for long-lasting changes in synaptic
function and memory storage. The importance of protein synthesis control to brain processes …

Sleep consolidates experience-dependent brain plasticity, but the precise cellular
mechanisms mediating this process are unknown [1]. De novo cortical protein synthesis is …

Mechanistic target of rapamcyin (mTOR) is a central player in cell growth throughout the
organism. However, mTOR takes on an additional, more specialized role in the developed …

Activity-dependent changes in synaptic structure and spine morphology are required for
learning and memory, and depend on protein translation. We show that the kinase for …

Interest in BDNF (brain-derived neurotrophic factor) as an activity-dependent modulator of
neuronal structure and function in the adult brain has intensified in recent years. Localization …