The unique abilities of human pluripotent stem cells to self-renew and to differentiate into
cells of the three germ layers make them an invaluable tool for the future of regenerative …

Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction
with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem …

Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-
thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several …

Reprogramming, or generation of induced pluripotent stem (iPS) cells (functionally similar to
embryonic stem cells or ES cells) by the use of transcription factors (typically: Oct3/4, Sox2, c …

Background Gastric cancer (GC) is one of the most common cancers in Iran. Knowledge of
the epidemiology of the disease is essential in planning for prevention. So this study aimed …

The stem cell-related transcription factor Oct4 regulates tumor proliferation and apoptosis,
but its role in tumor migration and invasion is still undefined. Here, we compared Oct4 …

Oct4A is a core component of the regulatory network of pluripotent cells, and by itself can
reprogram neural stem cells into pluripotent cells in mice and humans. However, its role in …

Octamer-binding transcription factor 4 (OCT4) has been implicated in cancer metastasis. In
this study, we investigated whether OCT4 promotes colorectal cancer (CRC) metastasis …

Background Expression of the essential regulator genes, SOX2, NANOG, and OCT4, so-
called as stemness factors, is prerequisite for the tumorigenic capability of cancer stem cells …

Purpose: We investigate the unknown tumor-killing activity of cytokine-induced killer (CIK)
cells against autologous metastatic melanoma and the elusive subset of putative cancer …