Electrostatic interactions in protein structure, folding, binding, and condensation
Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …
specific electrostatic interactions, impart important properties to proteins. Modulation of the …
[HTML][HTML] The use of polyoxometalates in protein crystallography–An attempt to widen a well-known bottleneck
A Bijelic, A Rompel - Coordination Chemistry Reviews, 2015 - Elsevier
Polyoxometalates (POMs) are discrete polynuclear metal-oxo anions with a fascinating
variety of structures and unique chemical and physical properties. Their application in …
variety of structures and unique chemical and physical properties. Their application in …
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
Many cellular proteins demix spontaneously from solution to form liquid condensates. These
phase-separated structures have wide-ranging roles in health and disease. Elucidating the …
phase-separated structures have wide-ranging roles in health and disease. Elucidating the …
Reentrant phase transition drives dynamic substructure formation in ribonucleoprotein droplets
Intracellular ribonucleoprotein (RNP) granules are membrane‐less droplet organelles that
are thought to regulate posttranscriptional gene expression. While liquid–liquid phase …
are thought to regulate posttranscriptional gene expression. While liquid–liquid phase …
[HTML][HTML] Model for disordered proteins with strongly sequence-dependent liquid phase behavior
Phase separation of intrinsically disordered proteins is important for the formation of
membraneless organelles or biomolecular condensates, which play key roles in the …
membraneless organelles or biomolecular condensates, which play key roles in the …
Phase separation of intrinsically disordered proteins
There is growing interest in the topic of intracellular phase transitions that lead to the
formation of biologically regulated biomolecular condensates. These condensates are …
formation of biologically regulated biomolecular condensates. These condensates are …
Do Ionic Liquids Exhibit the Required Characteristics to Dissolve, Extract, Stabilize, and Purify Proteins? Past-Present-Future Assessment
Proteins are highly labile molecules, thus requiring the presence of appropriate solvents and
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …
Human versus bovine serum albumin: a subtle difference in hydrophobicity leads to large differences in bulk and interface behavior
The protein human serum albumin (HSA) is able to readily crystallize in the presence of
trivalent cations, whereas this is not the case for the homologous protein in cattle, bovine …
trivalent cations, whereas this is not the case for the homologous protein in cattle, bovine …
Protein self-diffusion in crowded solutions
F Roosen-Runge, M Hennig, F Zhang… - Proceedings of the …, 2011 - National Acad Sciences
Macromolecular crowding in biological media is an essential factor for cellular function. The
interplay of intermolecular interactions at multiple time and length scales governs a fine …
interplay of intermolecular interactions at multiple time and length scales governs a fine …
[HTML][HTML] Why continuum electrostatics theories cannot explain biological structure, polyelectrolytes or ionic strength effects in ion–protein interactions
KD Collins - Biophysical chemistry, 2012 - Elsevier
Continuum electrostatics models for ions in water provide apparent long range electrostatic
explanations for the forces on ions. However the electro-chemical free energy of solvation of …
explanations for the forces on ions. However the electro-chemical free energy of solvation of …