Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

The HtrA family refers to a group of related oligomeric serine proteases that combine a
trypsin-like protease domain with at least one PDZ interaction domain. Mammals encode …

The dynamin-related protein Opa1 is localized to the mitochondrial intermembrane space,
where it facilitates fusion between mitochondria. Apoptosis causes Opa1 release into the …

The HtrA proteases degrade damaged proteins and thus control the quality of proteins and
protect cells against the consequences of various stresses; they also recognize specific …

The current study demonstrates a novel cross-talk mechanism between the TRAIL receptor
death signaling pathway and the mitochondria. This newly identified pathway is regulated at …

The human HtrA family of serine proteases consists of four members: HtrA1, HtrA2, HtrA3
and HtrA4. Although prokaryotic HtrA proteins are well characterized in their dual roles as …

DIABLO/Smac is a mitochondrial protein that can promote apoptosis by promoting the
release and activation of caspases. To do so, DIABLO/Smac must first be processed by a …

Importance of the field: The HtrA family proteins are serine proteases that are involved in
important physiological processes, including maintenance of mitochondrial homeostasis …

The processing and metabolism of amyloid precursor protein (APP) is a major interest in
Alzheimer disease (AD) research, because not only amyloid β (Aβ) peptide, but also cellular …

Apoptosis is triggered by two interconnected pathways, extrinsic and intrinsic. The intrinsic
pathway is activated by genomic stress promoting mitochondrial release of apoptotic …