SN38 is the active metabolite of irinotecan with 1000-fold greater cytotoxicity compared to
the parent drug. Despite the potential, its application as a drug is still seriously limited due to …

Ethyl-10-hydroxycamptothecin (SN38) is a biologically active metabolite of irinotecan. Due
to the variability of irinotecan metabolism rate to SN38, and poor solubility of this compound …

Abstract SN38 (7-ethyl-10-hydroxyl camptothecin), a potent metabolite of irinotecan, has
been considered as an anticancer candidate. Its clinical development has been hampered …

The formation of halogenated carboxylic acid intermediate followed by a ring-closing
reaction led to amino-functionalized asymmetrical lactide monomer. PEG-based functional …

7-Ethyl-10-hydroxy camptothecin (SN38) is a potent topoisomerase inhibitor and a
metabolite of irinotecan. Its clinical development has been hampered by its poor solubility …

The purpose of this study is to synthesize the new branched magnetic nanocomposite to
carry the therapeutic agents and bio-macromolecules. Although topotecan (TPT) has …

In conjunction with the rise in cancer incidence-mortality and handicaps of conventional poly
(ethylene glycol)-based polylactide, poly (lactide-co-glycolide), or poly (ε-caprolactone)(PEG …

A new highly reactive isobutyl lactide monomer (IBL) was synthesized with the ring closing
of halogenated carboxylic acid acquired by the reaction of (S)-2-hydroxy-4-methylpentanoic …

Because of the importance of glycolide-based polymers in materials and medical
applications, we have synthesized alternative novel thermosensitive biomaterials to be …

Abstract Irinotecan (IRT), the pro-drug of SN-38, has exhibited potent cytotoxicity against
various tumors. In order to enhance the anti-tumor effect of IRT, we prepared IRT-loaded …