DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome

A Duchon, Y Herault - Frontiers in behavioral neuroscience, 2016 - frontiersin.org
Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

Family variables and quality of life in children with down syndrome: A scoping review

A Lee, K Knafl, M Van Riper - International Journal of Environmental …, 2021 - mdpi.com
The purpose of this scoping review was to identify the family and child quality of life
variables that have been studied in relation to one another in children with Down syndrome …

[HTML][HTML] Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline

JH Cole, T Annus, LR Wilson, R Remtulla, YT Hong… - Neurobiology of …, 2017 - Elsevier
Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple
facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive …

Prevalence of aging, dementia, and multimorbidity in older adults with Down syndrome

E Bayen, KL Possin, Y Chen, LC de Langavant… - JAMA …, 2018 - jamanetwork.com
Importance As the life expectancy of people with Down syndrome (DS) has markedly
increased over the past decades, older adults with DS may be experiencing a higher …

Defining the real-world reproducibility of visual grading of left ventricular function and visual estimation of left ventricular ejection fraction: impact of image quality …

GD Cole, NM Dhutia, MJ Shun-Shin, K Willson… - The international journal …, 2015 - Springer
Left ventricular function can be evaluated by qualitative grading and by eyeball estimation of
ejection fraction (EF). We sought to define the reproducibility of these techniques, and how …

Clinical characteristics of individuals with Down syndrome deceased with CoVID‐19 in Italy—a case series

ER Villani, A Carfì, A Di Paola… - American Journal of …, 2020 - Wiley Online Library
BACKGROUND Persons with Down syndrome (DS) are presumed to be at high risk of
severe CoVID‐19, due to immune dysregulation and often compromised cardiopulmonary …

Family management of childhood chronic conditions: Does it make a difference if the child has an intellectual disability?

M Van Riper, GJ Knafl, C Roscigno… - American Journal of …, 2018 - Wiley Online Library
The purpose of this analysis was to assess the applicability of the Family Management
Measure (FaMM) to families in which there was a child with an intellectual disability versus a …

A Short‐Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome

M Rosety-Rodriguez, M Bernardi… - Oxidative Medicine …, 2021 - Wiley Online Library
Previous studies have found aerobic training improved oxidative damage in people with
Down syndrome (DS). However, there is a lack of information regarding the influence of …

Quality of life in individuals with Down syndrome aged 4 to 21 years

A Lee, G Knafl, K Knafl… - Child: Care, Health and …, 2021 - Wiley Online Library
Background To date, investigations of quality of life (QoL) in children with Down syndrome
(DS) are rather limited. The purpose of this study was twofold: to examine QoL in children …

Healthy ageing in people with intellectual disabilities from managers' perspective: a qualitative study

M Johansson, P Björne, I Runesson, G Ahlström - Healthcare, 2017 - mdpi.com
An increasing number of people with intellectual disability (ID) are reaching older ages
today although they experience more health problems than the older population without ID …