Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Photosensitizers for photodynamic therapy

M Lan, S Zhao, W Liu, CS Lee… - Advanced healthcare …, 2019 - Wiley Online Library
As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes
advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by …

In vivo metallophilic self-assembly of a light-activated anticancer drug

XQ Zhou, P Wang, V Ramu, L Zhang, S Jiang, X Li… - Nature Chemistry, 2023 - nature.com
Self-assembling molecular drugs combine the easy preparation typical of small-molecule
chemotherapy and the tumour-targeting properties of drug–nanoparticle conjugates …

Nanotechnology for multimodal synergistic cancer therapy

W Fan, B Yung, P Huang, X Chen - Chemical reviews, 2017 - ACS Publications
The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …

An overview on gold nanorods as versatile nanoparticles in cancer therapy

M Nejabat, A Samie, M Ramezani, M Alibolandi… - Journal of Controlled …, 2023 - Elsevier
Abstract Gold nanorods (GNRs/AuNRs) are a group of gold nanoparticles which their simple
surface chemistry allows for various surface modifications, providing the possibility of using …

The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials

L Zeng, P Gupta, Y Chen, E Wang, L Ji… - Chemical Society …, 2017 - pubs.rsc.org
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

Smart peptide-based supramolecular photodynamic metallo-nanodrugs designed by multicomponent coordination self-assembly

S Li, Q Zou, Y Li, C Yuan, R Xing… - Journal of the American …, 2018 - ACS Publications
Supramolecular photosensitizer nanodrugs that combine the flexibility of supramolecular
self-assembly and the advantage of spatiotemporal, controlled drug delivery are promising …

A Magnetofluorescent Carbon Dot Assembly as an Acidic H2O2‐Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced …

Q Jia, J Ge, W Liu, X Zheng, S Chen, Y Wen… - Advanced …, 2018 - Wiley Online Library
Recent studies indicate that carbon dots (CDs) can efficiently generate singlet oxygen (1O2)
for photodynamic therapy (PDT) of cancer. However, the hypoxic tumor microenvironment …