Integrative physiology of pneumonia

LJ Quinton, AJ Walkey, JP Mizgerd - Physiological reviews, 2018 - journals.physiology.org
Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Host defense antimicrobial peptides as antibiotics: design and application strategies

B Mishra, S Reiling, D Zarena, G Wang - Current opinion in chemical …, 2017 - Elsevier
Highlights•Antibiotic resistance is a serious problem of our era.•Antimicrobial peptides are
important templates for developing new antibiotics.•Both peptide discovery and application …

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults

C Langelier, KL Kalantar, F Moazed… - Proceedings of the …, 2018 - National Acad Sciences
Lower respiratory tract infections (LRTIs) lead to more deaths each year than any other
infectious disease category. Despite this, etiologic LRTI pathogens are infrequently …

The ecology of Nipah virus in Bangladesh: a nexus of land-use change and opportunistic feeding behavior in bats

CD McKee, A Islam, SP Luby, H Salje, PJ Hudson… - Viruses, 2021 - mdpi.com
Nipah virus is a bat-borne paramyxovirus that produces yearly outbreaks of fatal
encephalitis in Bangladesh. Understanding the ecological conditions that lead to spillover …

Antibiotic exposure and risk for hospital-associated Clostridioides difficile infection

BJ Webb, A Subramanian, B Lopansri… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is a health care-associated infection associated with
significant morbidity and cost, with highly varied risk across populations. More effective, risk …

Development of antiviral carbon quantum dots that target the Japanese encephalitis virus envelope protein

HH Chen, CJ Lin, A Anand, HJ Lin, HY Lin… - Journal of Biological …, 2022 - ASBMB
Japanese encephalitis is a mosquito-borne disease caused by the Japanese encephalitis
virus (JEV) that is prevalent in Asia and the Western Pacific. Currently, there is no effective …

Waning immunity and the second wave: Some projections for SARS-CoV-2

C Giannitsarou, S Kissler, F Toxvaerd - American Economic Review …, 2021 - aeaweb.org
This paper offers projections of future transmission dynamics for SARS-CoV-2 in an SEIRS
model with demographics and waning immunity. In a stylized optimal control setting …

Advantages and challenges of metagenomic sequencing for the diagnosis of pulmonary infectious diseases

Y Chen, LC Fan, YH Chai, JF Xu - The clinical respiratory …, 2022 - Wiley Online Library
Objective We aim to familiarize the application status of metagenomic sequencing in
diagnosing pulmonary infections, to compare metagenomic sequencing with traditional …

Pathogenesis of severe pneumonia: advances and knowledge gaps

JP Mizgerd - Current opinion in pulmonary medicine, 2017 - journals.lww.com
Recent findings will direct research into fundamental mechanisms of lung protection. Over
the longer term, manipulating these pathways has implications for clinical practice, as …

Clinically Unreported Salmonellosis Outbreak Detected via Comparative Genomic Analysis of Municipal Wastewater Salmonella Isolates

S Diemert, T Yan - Applied and environmental microbiology, 2019 - Am Soc Microbiol
Municipal wastewater includes human waste that contains both commensal and pathogenic
enteric microorganisms, and this collective community microbiome can be monitored for …