The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor
suppression, p53 is also involved in many other biological and pathological processes, such …

Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer,
with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently …

The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and
consequences that impact diverse cell types and tissues. Recent studies are beginning to …

Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all,
human cancers. Loss of functional wild-type p53 is achieved via two main mechanisms …

p53 is a transcription factor that regulates the expression of genes involved in tumor
suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of …

Simple Summary Despite remarkable progress being made by preventive medical check-
ups in the last decades, colorectal cancer (CRC) remains one of the most frequent and …

Simple Summary Cancer is largely caused by genetic alterations such as mutations in a
group of genes known as cancer driver genes. Many of the key advances in cancer …

Simple Summary Skin cancers are the most common types of cancer worldwide, and their
incidence is increasing. Epidermal keratinocyte-derived cutaneous squamous cell …