Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

The major types of osteoporosis in humans are postmenopausal osteoporosis, disuse
osteoporosis, and glucocorticoid-induced osteoporosis. Animal models for postmenopausal …

The innervation of bone has been described for centuries, and our understanding of its
function has rapidly evolved over the past several decades to encompass roles of subtype …

It is from the discovery of leptin and the central nervous system as a regulator of bone
remodeling that the presence of autonomic nerves within the skeleton transitioned from a …

Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

The skeleton is no longer seen as a static, isolated, and mostly structural organ. Over the last
two decades, a more complete picture of the multiple functions of the skeleton has emerged …

Recent advances in understanding the role of bone in the systemic regulation of energy
metabolism indicate that bone marrow cells, adipocytes and osteoblasts, are involved in this …

Type II deiodinase (D2) activates thyroid hormone by converting thyroxine (T4) to 3, 5, 3′-
triiodothyronine (T3). This allows plasma T4 to signal a negative feedback loop that inhibits …