The aim of this review is to provide a systematic overview on constitutively active G-protein-
coupled receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …

This review addresses novel concepts of histamine H1‐receptor function and attempts to
relate them to the anti‐inflammatory effects of H1‐antihistamines. Furthermore, the …

Since their discovery 13 years ago, chemokines have emerged as the most important
regulators of leukocyte trafficking. On target cells, chemokines bind to seven-transmembrane …

G-protein-coupled receptors (GPCRs) represent by far the largest class of targets for modern
drugs. Virtually all therapeutics that are directed towards GPCRs have been designed using …

Several examples of functional G-protein–coupled receptor heterodimers have been
identified. However, it is not known whether receptor heterodimerization is involved in the …

The vasopressor angiotensin II regulates vascular contractility and blood pressure through
binding to type 1 angiotensin II receptors (AT1; refs,). Bradykinin, a vasodepressor, is a …

The idea that G-protein-coupled receptors (GPCRs) can function as dimers is now generally
accepted. Although an increasing amount of data suggests that dimers represent the basic …

The existence of receptor dimers has been proposed for several G protein-coupled
receptors. However, the question of whether G protein-coupled receptor dimers are …

Although homodimerization has been demonstrated for a large number of G protein-coupled
receptors (GPCRs), no general role has been attributed to this process. Because it is known …

G-protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors in the human genome that respond to a plethora of signals, including …