Animal experimentation is necessary to characterize human diseases and design adequate
therapeutic interventions. In renal transplantation research, the limited number of in vitro …

This review deals with the latest advances in the study of embryonic stem cells (ESC) and
induced pluripotent stem cells (iPSC) from domesticated species, with a focus on pigs, cattle …

For reasons that are unclear the production of embryonic stem cells from ungulates has
proved elusive. Here, we describe induced pluripotent stem cells (iPSC) derived from …

Domesticated ungulate pluripotent embryonic stem (ES) cell lines would be useful for
generating precise gene-modified animals. To date, many efforts have been made to …

Since domestication, pigs have been used extensively in agriculture and kept as companion
animals. More recently they have been used in biomedical research, given they share many …

Background Because few studies exist to describe the unique molecular network regulation
behind pig pre-implantation embryonic development (PED), genetic engineering in the pig …

The development of the induced pluripotent stem cells (iPSC s) technology has
revolutionized the world on the establishment of pluripotent stem cells (PSC s) across a …

Genetic engineering in livestock was greatly enhanced by the emergence of clustered
regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) …

Activin/Nodal signaling is required for maintaining pluripotency and self-renewal of mouse
epiblast stem cells and human embryonic stem cells (hESC). In this study, we investigated …

Authentic or naïve embryonic stem cells (ESC) have probably never been derived from the
inner cell mass (ICM) of pig blastocysts, despite over 25 years of effort. Recently, several …