A systematic review of the protective effects of silymarin/silibinin against doxorubicin-induced cardiotoxicity

M Singh, MM Kadhim, A Turki Jalil, SK Oudah… - Cancer Cell …, 2023 - Springer
Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …

[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach… - Redox biology, 2017 - Elsevier
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Silybin and its congeners: From traditional medicine to molecular effects

V Křen, K Valentová - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2015 up to 2022 (Feb) Silymarin, an extract of milk thistle (Silybum marianum)
fruits, has been used in various medicinal applications since ancient times. A major …

Natural antioxidants as stabilizers for polymers

B Kirschweng, D Tátraaljai, E Földes… - Polymer Degradation and …, 2017 - Elsevier
The additive packages routinely used today usually consist of a phenolic antioxidant and a
phosphorus or sulfur containing secondary stabilizer. Several years ago some questions …

The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence

I Marmouzi, A Bouyahya, SM Ezzat, M El Jemli… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Silybum marianum (L.) Gaertn. or Milk thistle is a
medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. It …

Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin

V Tvrdý, J Pourová, E Jirkovský, V Křen… - Medicinal Research …, 2021 - Wiley Online Library
Silymarin is an extract from the seeds (fruits) of Silybum marianum that contains
flavonolignans and flavonoids. Although it is frequently used as a hepatoprotective agent, its …

Antioxidant function of phytocannabinoids: Molecular basis of their stability and cytoprotective properties under UV-irradiation

J Vacek, J Vostalova, B Papouskova… - Free Radical Biology …, 2021 - Elsevier
In this contribution, a comprehensive study of the redox transformation, electronic structure,
stability and photoprotective properties of phytocannabinoids is presented. The non …

Oxidative stress evaluation in ischemia reperfusion models: characteristics, limits and perspectives

P Chazelas, C Steichen, F Favreau, P Trouillas… - International Journal of …, 2021 - mdpi.com
Ischemia reperfusion injury is a complex process consisting of a seemingly chaotic but
actually organized and compartmentalized shutdown of cell function, of which oxidative …

Chirality Matters: Biological activity of optically pure silybin and its congeners

V Křen - International Journal of Molecular Sciences, 2021 - mdpi.com
This review focuses on the specific biological effects of optically pure silymarin flavo-
nolignans, mainly silybins A and B, isosilybins A and B, silychristins A and B, and their 2, 3 …

Redox properties of individual quercetin moieties

E Heřmánková, M Zatloukalová, M Biler… - Free Radical Biology …, 2019 - Elsevier
Quercetin is one of the most prominent and widely studied flavonoids. Its oxidation has been
previously investigated only indirectly by comparative analyses of structurally analogous …