Lesions with the neurotoxin 6-hydroxydopamine (6-OHDA) have provided an important tool
to study dopamine neurons in the brain. The most common version of such lesions is the …

Accurate and continuous in vivo measurements of brain interstitial substance concentrations
provide a major technical challenge. Among the many innovations that have appeared over …

Abstract In the unilateral 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's
disease, controversy exists concerning the use of apomorphine-or d-amphetamine-induced …

Growth factors are becoming extremely valuable tools in our attempts to understand the
mechanisms that modulate cellular activities. Their targeting to appropriate cells and …

Autologous adrenal medullary tissue was transplanted unilaterally to the putamen in two
patients with severe Parkinson's disease. The first patient exhibited a transient, two‐day …

• In an effort to improve the clinical signs of Parkinson's disease, we have implanted
mesencephalic dopamine cells from a 7-week human embryo into the caudate and putamen …

We have used a rat model of Parkinson's disease (PD) to address issues of importance for a
future clinical application of dopamine (DA) neuron grafting in patients with PD. Human …

The successful grafting of homotopic tissue (see Table 1 for terminology), ie neuronal tissue,
to the brain has recently increased the interest in the brain as an immunologically privileged …

• Experimental studies in rodents show that β-nerve growth factor can increase the survival,
neurite outgrowth, and functional effect of grafts of adrenal chromaffin cells to the basal …

Although grafted adrenal medullary tissue to the striatum has been used both experimentally
and clinically in parkinsonism, there is a definite need to augment long-term survival …