Chemically modified platforms for better RNA therapeutics

Y Shi, X Zhen, Y Zhang, Y Li, S Koo, Q Saiding… - Chemical …, 2024 - ACS Publications
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

Transfer RNAs-derived small RNAs and their application potential in multiple diseases

X Chu, C He, B Sang, C Yang, C Yin, M Ji… - Frontiers in cell and …, 2022 - frontiersin.org
The role of tRNAs is best known as adapter components of translational machinery.
According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn …

Detecting RNA–RNA interactome

S Singh, S Shyamal, AC Panda - Wiley Interdisciplinary …, 2022 - Wiley Online Library
The last decade has seen a robust increase in various types of novel RNA molecules and
their complexity in gene regulation. RNA molecules play a critical role in cellular events by …

The ratio of toxic-to-Nontoxic mirnas predicts platinum sensitivity in ovarian cancer

M Patel, Y Wang, ET Bartom, R Dhir, KP Nephew… - Cancer research, 2021 - AACR
Ovarian cancer remains one of the deadliest gynecologic malignancies affecting women,
and development of resistance to platinum remains a major barrier to achieving a cure …

DISE/6mer Seed Toxicity-A powerful anti-cancer mechanism with implications for other diseases

A Haluck-Kangas, M Patel, B Paudel… - Journal of Experimental …, 2021 - Springer
Abstract micro (mi) RNAs are short noncoding RNAs that through their seed sequence (pos.
2–7/8 of the guide strand) regulate cell function by targeting complementary sequences …

AGO CLIP-based imputation of potent siRNA sequences targeting SARS-CoV-2 with antifibrotic miRNA-like activity

SH Ahn, D Gu, Y Koh, HS Lee, SW Chi - Scientific reports, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is associated with fatal pulmonary fibrosis. Small …

Regulation of Circulating miR-342-3p Alleviates the Radiation-Induced Immune System Injury

W Wei, H Bai, T Zhang, S Cai, Y Zhou… - Radiation …, 2023 - meridian.allenpress.com
Ionizing radiation in space, radiation devices or nuclear disasters are major threats to
human health and public security. Expanding countermeasures for dealing with accidental …

[HTML][HTML] RNA-RNA competitive interactions: a molecular civil war ruling cell physiology and diseases

C Barbagallo, M Stella, C Ferrara… - Exploration of …, 2023 - explorationpub.com
The idea that proteins are the main determining factors in the functioning of cells and
organisms, and their dysfunctions are the first cause of pathologies, has been predominant …

CircCOPS8 inhibits the proliferation of buffalo myoblasts by binding to IGF2BP3 and promoting tumor suppressor gene expression

P Sun, Y Dou, M Chen, M Song, X Qu, Y Huang… - 2023 - researchsquare.com
Background Buffalo is a characteristic species in Guangxi, whose meat is nutrient-dense
and good for the human body because of its polyunsaturated fatty acids and conjugated …

[HTML][HTML] NEAT1 variant 1 weakens the genome-wide effect of miR-3122 on blocking H3K79me3 in bladder cancer

W Zhao, F Sun, L Zhang, J Ouyang - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Nuclear-enriched abundant transcript 1 (NEAT1) is one of the most well-studied long non-
coding RNAs (lncRNAs) in multiple human carcinoma. Two distinct variants of NEAT1 …