The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network
that plays a critical role in various biological processes, including cellular metabolism …

It has been unequivocally established that kynurenic acid has a number of actions in a
variety of cells and tissues, raising, in principle, the possibility of targeting its generation …

Plasma nonesterified fatty acids (NEFA) are elevated in cancer, because of decreased
albumin levels and of fatty acid oxidation, and increased fatty acid synthesis and lipolysis …

Most ER+ breast cancers (BC) express androgen receptors (AR). This randomized phase II
trial of 4 months of neoadjuvant fulvestrant (Fulv) alone or with enzalutamide (Combo) …

Proper nutrition and supplementation during pregnancy and breastfeeding are crucial for the
development of offspring. Kynurenine (KYN) is the central metabolite of the kynurenine …

Tryptophan (Trp) metabolism plays a vital role in cancer immunity. Indoleamine 2.3-
dioxygenase 1 (IDO1), is a crucial enzyme in the metabolic pathway by which Trp is …

Background Glioblastoma is an aggressive brain cancer, usually of unknown etiology, and
with a very poor prognosis. Survival from diagnosis averages only 3 months if left untreated …

Background Non-alcoholic steatohepatitis (NASH) is a rapidly progressing chronic liver
disease of global significance. However, the underlying mechanisms responsible for NASH …

Immunometabolism plays a central role in sustaining immune system functionality and
preserving physiological homeostasis within the organism. During the differentiation and …

The kynurenine pathway (KP) and associated catabolites play key roles in promoting tumor
progression and modulating the host anti-tumor immune response. To date, considerable …