During the final prenatal period of fetal lung development in humans, important maturational
processes occur, including the production of surfactant necessary to decrease surface …

Introduction 3. Transcriptional control of lung development 4. Growth factors and lung
development 4.1. EGF, TGFα and EGFR 4.2. Fibroblasts Growth Factors (FGFs) and their …

During lung development there is tension between positive and negative regulators of
fibroblast-epithelial communication controlling type II cell differentiation. A clinical …

Organized and coordinated lung development follows transcriptional regulation of a
complex set of cell-cell and cell-matrix interactions resulting in a blood-gas interface ready …

Lung maturation is delayed in male fetuses compared with female fetuses, which has been
attributed to higher levels of androgens in the male lung. Our previous studies demonstrated …

During late pregnancy, the fetal lung stores surfactant in preparation for extrauterine life.
Surfactant deficiency, most often due to prematurity, precipitates respiratory distress …

The ErbB4 receptor has an important function in fetal lung maturation. Deletion of ErbB4
leads to alveolar hypoplasia and hyperreactive airways similar to the changes in …

Surfactant synthesis within developing fetal lung type II cells is affected by testosterone and
5α-dihydrotestosterone (5α-DHT). The pulmonary epithelial cell line A549, isolated from a …

Objective: Epidermal growth factor has been shown to play an important role in prenatal and
postnatal lung development, but little is known about its effects on adult lung growth. We …

Male sex remains an independent risk factor for respiratory distress syndrome (RDS) in
preterm infants. Insufficient Na+ transport-mediated alveolar fluid clearance contributes to …