Almost half of the human genome is made up of transposable elements (TEs), and about 8%
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …

Endogenous retroviruses (ERVs), deriving from exogenous retroviral infections of germ line
cells occurred millions of years ago, represent~ 8% of human genome. Most ERVs are …

Background Transposable element-embedded regulatory sequences (TEeRS) and their
KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as …

Transposable element (TE) invasions have shaped vertebrate genomes over the course of
evolution. They have contributed an extra layer of species-specific gene regulation by …

Krüppel-associated box zinc finger proteins (KZFPs) function as a defense mechanism to
maintain the genome stability of higher vertebrates by regulating the transcriptional activities …

The human genome has been under selective pressure to evolve in response to emerging
pathogens and other environmental challenges. Genome evolution includes the acquisition …

Nonalcoholic fatty liver disease (NAFLD) has become a major global health problem with no
approved pharmacological treatment for this disease. Thus, it is urgent to develop effective …

Most transposable elements (TEs) in the mouse genome are heavily modified by DNA
methylation and repressive histone modifications. However, a subset of TEs exhibit variable …

Numerous reference genes for use with quantitative reverse transcription polymerase chain
reaction (RT-qPCR) have been used for oocytes, eggs, and preimplantation embryos …

Background Dysfunctional p53 signaling is one of the major causes of hepatocellular
carcinoma (HCC) tumorigenesis and development, but the mechanisms underlying p53 …