Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to …

Background Multiple sclerosis is an acquired demyelinating disease of the central nervous
system. It is the second most common cause of disability in adults in United States after head …

Major progress has been made during the past three decades in understanding the
inflammatory process and pathogenetic mechanisms in multiple sclerosis (MS) …

Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

MS is heterogeneous with respect to clinical, genetic, radiographic, and pathologic features;
surrogate MRI, clinical, genetic, serologic, and/or CSF markers for each of the four …

Some recent studies suggest that in progressive multiple sclerosis, neurodegeneration may
occur independently from inflammation. The aim of our study was to analyse the …

Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying
degrees of brain atrophy beyond that of normal aging. Assessment of atrophy helps to …

Objective Thalamic volume is a candidate magnetic resonance imaging (MRI)‐based
marker associated with neurodegeneration to hasten development of neuroprotective …

In multiple sclerosis (MS), diffuse degenerative processes in the deep grey matter have
been associated with clinical disabilities. We performed a systematic study in MS deep grey …