[HTML][HTML] Sec-and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—distinct translocases and mechanisms
In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane.
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
Mechanisms of Sec61/SecY-mediated protein translocation across membranes
E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
Protein translocation across the bacterial cytoplasmic membrane
AJM Driessen, N Nouwen - Annu. Rev. Biochem., 2008 - annualreviews.org
About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …
[HTML][HTML] Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR
I Gelis, AMJJ Bonvin, D Keramisanou, M Koukaki… - Cell, 2007 - cell.com
Recognition of signal sequences by cognate receptors controls the entry of virtually all
proteins to export pathways. Despite its importance, this process remains poorly understood …
proteins to export pathways. Despite its importance, this process remains poorly understood …
[HTML][HTML] The sec translocase
DJF Du Plessis, N Nouwen, AJM Driessen - Biochimica et Biophysica Acta …, 2011 - Elsevier
The vast majority of proteins trafficking across or into the bacterial cytoplasmic membrane
occur via the translocon. The translocon consists of the SecYEG complex that forms an …
occur via the translocon. The translocon consists of the SecYEG complex that forms an …
The Sec translocon mediated protein transport in prokaryotes and eukaryotes
K Denks, A Vogt, I Sachelaru, NA Petriman… - Molecular membrane …, 2014 - Taylor & Francis
Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …
Bacterial protein secretion through the translocase nanomachine
E Papanikou, S Karamanou, A Economou - Nature Reviews …, 2007 - nature.com
All cells must traffic proteins across their membranes. This essential process is responsible
for the biogenesis of membranes and cell walls, motility and nutrient scavenging and uptake …
for the biogenesis of membranes and cell walls, motility and nutrient scavenging and uptake …
Conformational transition of Sec machinery inferred from bacterial SecYE structures
Over 30% of proteins are secreted across or integrated into membranes. Their newly
synthesized forms contain either cleavable signal sequences or non-cleavable membrane …
synthesized forms contain either cleavable signal sequences or non-cleavable membrane …
The bacterial Sec-translocase: structure and mechanism
JA Lycklama a Nijeholt… - … Transactions of the …, 2012 - royalsocietypublishing.org
Most bacterial secretory proteins pass across the cytoplasmic membrane via the
translocase, which consists of a protein-conducting channel SecYEG and an ATP …
translocase, which consists of a protein-conducting channel SecYEG and an ATP …
The Sec System: Protein Export in Escherichia coli
JM Crane, LL Randall - EcoSal Plus, 2017 - Am Soc Microbiol
In Escherichia coli, proteins found in the periplasm or the outer membrane are exported from
the cytoplasm by the general secretory, Sec, system before they acquire stably folded …
the cytoplasm by the general secretory, Sec, system before they acquire stably folded …