The general structural features of the motor region of myosin superfamily members are now
well established, as is a subset of the structural and kinetic transitions of the actin-myosin …

Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

Regulation of myosin and filamentous actin interaction by tropomyosin is a central feature of
contractile events in muscle and nonmuscle cells. However, little is known about molecular …

Publisher Summary This chapter describes the analysis of the polymorphism of the myosin
crossbridge and relates it to the Lymn–Taylor crossbridge cycle. Myosin from muscle …

Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride
concentrations in surface water are low and fluorinated metabolites are extremely rare,. The …

How myosin interacts with actin to generate force is a subject of considerable controversy.
The major debate centers on understanding at what point in force generation the inorganic …

Muscle contraction involves the cyclic interaction of the myosin cross-bridges with the actin
filament, which is coupled to steps in the hydrolysis of ATP. While bound to actin each cross …

The molecular motor, myosin, undergoes conformational changes in order to convert
chemical energy into force production. Based on kinetic and structural considerations, we …

By representing the high-resolution crystal structures of a number of enzymes using the
elastic network model, it has been shown that only a few low-frequency normal modes are …

Abstract Here we solve a 2.4-Å structure of a truncated version of the reverse-direction
myosin motor, myosin VI, that contains the motor domain and binding sites for two …