Biomanufacturing for clinically advanced cell therapies
The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies
to the market. To address the demands of the clinical and eventual commercial-scale …
to the market. To address the demands of the clinical and eventual commercial-scale …
Advanced biomaterials in cell preservation: Hypothermic preservation and cryopreservation
Cell-based medicine has made great advances in clinical diagnosis and therapy for various
refractory diseases, inducing a growing demand for cell preservation as support technology …
refractory diseases, inducing a growing demand for cell preservation as support technology …
Continuous microfluidic encapsulation of single mesenchymal stem cells using alginate microgels as injectable fillers for bone regeneration
The encapsulation of cells in microscale hydrogels can provide a mimic of a three-
dimensional (3D) microenvironment to support cell viability and functions and to protect cells …
dimensional (3D) microenvironment to support cell viability and functions and to protect cells …
A roadmap for cost-of-goods planning to guide economic production of cell therapy products
YY Lipsitz, WD Milligan, I Fitzpatrick, E Stalmeijer… - Cytotherapy, 2017 - Elsevier
Cell therapy products are frequently developed and produced without incorporating cost
considerations into process development, contributing to prohibitively costly products …
considerations into process development, contributing to prohibitively costly products …
Alginate-encapsulation for the improved hypothermic preservation of human adipose-derived stem cells
S Swioklo, A Constantinescu… - Stem cells translational …, 2016 - academic.oup.com
Despite considerable progress within the cell therapy industry, unmet bioprocessing and
logistical challenges associated with the storage and distribution of cells between sites of …
logistical challenges associated with the storage and distribution of cells between sites of …
The Human Cell Atlas: technical approaches and challenges
Abstract The Human Cell Atlas is a large, international consortium that aims to identify and
describe every cell type in the human body. The comprehensive cellular maps that arise …
describe every cell type in the human body. The comprehensive cellular maps that arise …
Influence of hypothermic storage fluids on mesenchymal stem cell stability: a comprehensive review and personal experience
A Ścieżyńska, M Soszyńska, P Szpak, N Krześniak… - Cells, 2021 - mdpi.com
Mesenchymal stem cells have generated a great deal of interest due to their potential use in
regenerative medicine and tissue engineering. Examples illustrating their therapeutic value …
regenerative medicine and tissue engineering. Examples illustrating their therapeutic value …
On-demand regulation of dual thermosensitive protein hydrogels
WW Song, ZG Qian, H Liu, HF Chen… - ACS Macro …, 2021 - ACS Publications
Despite considerable progress having been made in thermosensitive protein hydrogels,
regulating their thermal transitions remains a challenge due to the intricate molecular …
regulating their thermal transitions remains a challenge due to the intricate molecular …
[HTML][HTML] From production to patient: challenges and approaches for delivering cell therapies
K Coopman, N Medcalf - 2014 - europepmc.org
The cell therapy industry is rapidly growing with several new products approved for clinical
use over the past few years and many more currently in clinical trials. Nonetheless, a …
use over the past few years and many more currently in clinical trials. Nonetheless, a …
The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells
G Hajmousa, P Vogelaar, LA Brouwer… - Biomaterials, 2017 - Elsevier
Encouraging advances in cell therapy research with adipose derived stem cells (ASC)
require an effective short-term preservation method that provides time for quality control and …
require an effective short-term preservation method that provides time for quality control and …