Known for over a century, reactions that involve intramolecular hydride‐transfer events have
experienced a recent resurgence. Undoubtedly responsible for the increased interest in this …

The development of new strategies for synthesis of medium-sized heterocycles has
remained a highly attractive but challenging proposition. In the last few years, the application …

Chiral phosphoric acid-catalyzed asymmetric C− H functionalization has been achieved. In
this process, enantiotopic C (sp3)− hydrogen is selectively activated by chiral phosphoric …

Aminobenzaldehydes react with indoles in an unprecedented cascade reaction. This acid-
catalyzed redox-neutral annulation proceeds via a condensation/1, 5-hydride shift/ring …

The direct functionalization of C (sp3)–H bonds is one of the most synthetically powerful
research areas in current organic synthesis. Organocatalytic C (sp3)–H bond activation …

Cyclic secondary amines and 2-hydroxybenzaldehydes or related ketones react to furnish
benzo [e][1, 3] oxazine structures in generally good yields. This overall redox-neutral amine …

Described herein are two novel types of double C (sp3)–H bond functionalizations triggered
by a sequential hydride shift/cyclization process:(1) construction of a bicyclo [3.2. 2] nonane …

The borane-catalyzed synthesis of dihydroquinoline-4-ones is developed. The amino-
substituted chalcones undergo a 1, 7-hydride shift upon Lewis acid activation to form a …

p300/CREB binding protein associated factor (PCAF/KAT2B) and general control
nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in …

Abstract The cascade [1, n]-hydrogen transfer/cyclization, recognized as the tert amino effect
one century ago, has received considerable interest in recent decades, and great …