Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

Skin cutaneous melanoma (SKCM, hereafter referred to as melanoma) is the most lethal
skin cancer with increasing incidence. Regulated cell death plays an important role in …

Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …

Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …

Regulatory T cells (T regs) are a barrier to anti-tumor immunity. Neuropilin-1 (Nrp1) is
required to maintain intratumoral T reg stability and function but is dispensable for peripheral …

Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …

The immune system maintains a critically organized network to defend against foreign
particles, while evading self-reactivity simultaneously. T lymphocytes function as effectors …

CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic
heterogeneity reflecting the diverse environments and target cells that they regulate. To …

It has recently become apparent that the immune system can cure cancer. In some of these
strategies, the antigen targets are preidentified and therapies are custom-made against …