Autoimmune diseases are a range of diseases in which the immune response to self-
antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic …

The purpose of studying the epidemiology of multiple sclerosis (MS) is twofold. First, it is
important to understand clearly the natural history of the illness in order to assist patients in …

Data on familial recurrence rates of complex diseases such as multiple sclerosis give
important hints to aetiological factors such as the importance of genes and environment. By …

Multiple sclerosis (MS) is more prevalent in females than males, and this female
predominance is increasing as time goes by. Additionally, gender appears to play critical …

Background MS pathogenesis seems to involve both genetic susceptibility and
environmental risk factors. Three sequential factors are implicated in the environmental risk …

MS-pathogenesis involves both genetic-susceptibility and environmental determinants.
Three (or more) sequential environmental-factors are implicated. The first acts near birth, the …

The genetics of complex disease is entering a new and exciting era. The exponentially
growing knowledge and technological capabilities emerging from the human genome …

Background: Multiple sclerosis (MS) is a complex neurologic disease of unknown etiology
and inheritance pattern, but with increasing incidence among females. The study of …

The role of gender in the natural history of multiple sclerosis (MS) is multi-faceted. Earliest
debate on this topic was about the sex ratio (female: male) among affected individuals. It …

Objective To investigate the parental relationship of patients with multiple sclerosis (MS)
from an extended pedigree with extensive genealogical information up to the middle of the …