The human virome: viral metagenomics, relations with human diseases, and therapeutic applications

GH Bai, SC Lin, YH Hsu, SY Chen - Viruses, 2022 - mdpi.com
The human body is colonized by a wide range of microorganisms. The field of viromics has
expanded since the first reports on the detection of viruses via metagenomic sequencing in …

Predictive biomarkers for checkpoint inhibitor immune-related adverse events

I Les, M Martinez, I Perez-Francisco, M Cabero… - Cancers, 2023 - mdpi.com
Simple Summary Immune-checkpoint inhibitors (ICIs) are increasingly used in the treatment
of cancer, but they cause immune-related adverse events (irAEs) in around 40% of patients …

Association of Helicobacter pylori infection with survival outcomes in advanced gastric cancer patients treated with immune checkpoint inhibitors

H Che, Q Xiong, J Ma, S Chen, H Wu, H Xu, B Hou - BMC cancer, 2022 - Springer
Background Accumulating evidence has revealed that the gut microbiota influences the
effectiveness of immune checkpoint inhibitors (ICIs) in cancer patients. As a part of the …

Bacterial extracellular vesicles in gastrointestinal tract cancer: an unexplored territory

SB Amatya, S Salmi, V Kainulainen, P Karihtala… - Cancers, 2021 - mdpi.com
Simple Summary Microbial dysbiosis has been credited as one of the contributing factors to
the development and progression of gastrointestinal tract cancer. The altered microbiota …

Personalized immunotherapy in colorectal cancers: where do we stand?

LF Hu, HR Lan, D Huang, XM Li, KT Jin - Frontiers in oncology, 2021 - frontiersin.org
Colorectal cancer (CRC) is the second leading cause of cancer death in the world.
Immunotherapy using monoclonal antibodies, immune-checkpoint inhibitors, adoptive cell …

The gastrointestinal microbiota in colorectal cancer cell migration and invasion

C Henstra, J van Praagh, P Olinga… - Clinical & Experimental …, 2021 - Springer
Colorectal carcinoma is the third most common cancer in developed countries and the
second leading cause of cancer-related mortality. Interest in the influence of the intestinal …

Advances and new frontiers for immunotherapy in colorectal cancer: Setting the stage for neoadjuvant success?

N Sumransub, K Vantanasiri, A Prakash… - Molecular Therapy …, 2021 - cell.com
Immunotherapy in the metastatic setting has drastically altered the landscape of treatment
for various types of malignancy, including colorectal cancer. The category of immune …

Effect of gut microbiota in the colorectal cancer and potential target therapy

J Li, Y Zhu, L Yang, Z Wang - Discover Oncology, 2022 - Springer
The symbiotic interaction between gut microbiota and the digestive tract is an important
factor in maintaining the intestinal environment balance. Colorectal cancer (CRC) is a …

Transfer of modified gut viromes improves symptoms associated with metabolic syndrome in obese male mice

X Mao, SB Larsen, LSF Zachariassen, A Brunse… - Nature …, 2024 - nature.com
Metabolic syndrome encompasses amongst other conditions like obesity and type-2
diabetes and is associated with gut microbiome (GM) dysbiosis. Fecal microbiota …

Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio-and immunotherapy treatment of colorectal cancer

L Van Dingenen, C Segers, S Wouters… - Frontiers in Cellular …, 2023 - frontiersin.org
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and poses a
major burden on the human health worldwide. At the moment, treatment of CRC consists of …