Zinc in human health and infectious diseases

M Maywald, L Rink - Biomolecules, 2022 - mdpi.com
During the last few decades, the micronutrient zinc has proven to be an important metal ion
for a well-functioning immune system, and thus also for a suitable immune defense …

Role of zinc in female reproduction

TB Garner, JM Hester, A Carothers… - Biology of …, 2021 - academic.oup.com
Zinc is a critical component in a number of conserved processes that regulate female germ
cell growth, fertility, and pregnancy. During follicle development, a sufficient intracellular …

DYRK1A inhibitors as potential therapeutics for β-cell regeneration for diabetes

K Kumar, C Suebsuwong, P Wang… - Journal of Medicinal …, 2021 - ACS Publications
According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …

How cellular Zn2+ signaling drives physiological functions

N Levaot, M Hershfinkel - Cell Calcium, 2018 - Elsevier
Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

The role of 8-amidoquinoline derivatives as fluorescent probes for zinc ion determination

NS Mohamad, NH Zakaria, N Daud, LL Tan, GC Ta… - Sensors, 2021 - mdpi.com
Mass-spectrometry-based and X-ray fluorescence-based techniques have allowed the study
of the distribution of Zn2+ ions at extracellular and intracellular levels over the past few …

Neuronal signalling of zinc: From detection and modulation to function

C Zhang, A Dischler, K Glover, Y Qin - Open Biology, 2022 - royalsocietypublishing.org
Zinc is an essential trace element that stabilizes protein structures and allosterically
modulates a plethora of enzymes, ion channels and neurotransmitter receptors. Labile zinc …

HaloTag-based hybrid targetable and ratiometric sensors for intracellular zinc

ML Zastrow, Z Huang, SJ Lippard - ACS Chemical Biology, 2020 - ACS Publications
We report a new series of small molecule–protein hybrid zinc sensors that combine genetic
targetability with the spectroscopic profile of synthetic fluorophores. We functionalized the …

Metal binding properties of zinc fingers with a naturally altered metal binding site

K Kluska, J Adamczyk, A Krężel - Metallomics, 2018 - academic.oup.com
Zinc fingers (ZFs) are among the most abundant motifs found in proteins, and are commonly
known for their structural role. Classical ZFs (CCHH) are part of the transcription factors that …

[HTML][HTML] Crosstalk between zinc and free fatty acids in plasma

JPC Coverdale, S Khazaipoul, S Arya… - … et Biophysica Acta (BBA …, 2019 - Elsevier
In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids,
other lipids and hydrophobic molecules including neurodegenerative peptides, and …

ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion

Y Golan, R Alhadeff, A Warshel… - PLOS Computational …, 2019 - journals.plos.org
Zinc is a vital trace element crucial for the proper function of some 3,000 cellular proteins.
Specifically, zinc is essential for key physiological processes including nucleic acid …