Current treatment landscape for advanced hepatocellular carcinoma: patient outcomes and the impact on quality of life

D Li, S Sedano, R Allen, J Gong, M Cho, S Sharma - Cancers, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading
cause of cancer mortality worldwide. Heterogeneity of clinical conditions contributes to the …

Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma

SG Swamy, VH Kameshwar, PB Shubha, CY Looi… - Targeted …, 2017 - Springer
Hepatocellular carcinoma (HCC) is one of the most common forms of liver cancer diagnosed
worldwide. HCC occurs due to chronic liver disease and is often diagnosed at advanced …

Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

Q Fan, L Yang, X Zhang, Y Ma, Y Li, L Dong… - Journal of Experimental …, 2018 - Springer
Background Autophagy is a dynamic physiological process that can generate energy and
nutrients for cell survival during stress. Autophagy can regulate the migration and invasive …

The expression profiles and prognostic values of HSP70s in hepatocellular carcinoma

B Wang, T Lan, H Xiao, ZH Chen, C Wei, LF Chen… - Cancer cell …, 2021 - Springer
Background The HSP70 family of heat shock protein plays a critical role in protein synthesis
and transport to maintain protein homeostasis. Several studies have indicated that HSP70s …

68Ga-PSMA-11 PET/CT improves tumor detection and impacts management in patients with hepatocellular carcinoma

N Hirmas, C Leyh, M Sraieb, F Barbato… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the third most
frequent cause of cancer-related death. A growing number of local and systemic therapies …

[HTML][HTML] LncRNA-ATB promotes autophagy by activating Yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma

CZ Wang, GX Yan, DS Dong, H Xin… - World journal of …, 2019 - ncbi.nlm.nih.gov
BACKGROUND Long non-coding RNAs (lncRNAs) play important roles in many diseases,
including hepatocellular carcinoma (HCC). Autophagy is a metabolic pathway that facilitates …

Synthesis and preclinical evaluation of a 68Ga-labeled adnectin, 68Ga-BMS-986192, as a PET agent for imaging PD-L1 expression

S Robu, A Richter, D Gosmann, C Seidl… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Blocking the interaction of the immune checkpoint molecule programmed cell death protein-
1 and its ligand, PD-L1, using specific antibodies has been a major breakthrough for …

[HTML][HTML] Mouse IP-10 gene delivered by folate-modified chitosan nanoparticles and dendritic/tumor cells fusion vaccine effectively inhibit the growth of hepatocellular …

Z Hu, J Chen, S Zhou, N Yang, S Duan, Z Zhang… - Theranostics, 2017 - ncbi.nlm.nih.gov
Dendritic cells (DC) and tumor cell fusion vaccine (DC/tumor cell fusion vaccine) is
considered an effective approach in cancer biotherapy. However, its therapeutic effects in …

A novel prognostic index of hepatocellular carcinoma based on immunogenomic landscape analysis

H Xiao, B Wang, HX Xiong, JF Guan… - Journal of cellular …, 2021 - Wiley Online Library
Abstract Changes in immune responses to hepatocellular carcinoma (HCC) are closely
related to the occurrence, development, and prognosis of this disease. Exploring the role of …

MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

G Wang, X Fang, M Han… - … journal of molecular …, 2018 - spandidos-publications.com
The aim of the present study was to explore the role of miR‑493-5p in liver cancer tissues
and cell lines, and its effect on cell behavioral characteristics. The expression of miR-493-5p …