Application of metabolomics to the discovery of biomarkers for ischemic stroke in the murine model: a comparison with the clinical results

J Jia, H Zhang, X Liang, Y Dai, L Liu, K Tan, R Ma… - Molecular …, 2021 - Springer
Ischemic stroke (IS) is a major cause of mortality and disability worldwide. However, the
pathogenesis of IS remains unknown, and methods for early prediction and diagnosis of IS …

Hippocampal region-specific endogenous neuroprotection as an approach in the search for new neuroprotective strategies in ischemic stroke. Fiction or fact?

M Beresewicz-Haller - Neurochemistry International, 2023 - Elsevier
Ischemic stroke is the leading cause of death and long-term disability worldwide, and, while
considerable progress has been made in understanding its pathophysiology, the lack of …

Validation of the reference genes for expression analysis in the Hippocampus after transient ischemia/reperfusion injury in gerbil brain

A Lewczuk, A Boratyńska-Jasińska… - International Journal of …, 2023 - mdpi.com
Transient brain ischemia in gerbils is a common model to study the mechanisms of neuronal
changes in the hippocampus. In cornu ammonnis 2–3, dentate gyrus (CA2-3, DG) regions of …

Mitochondrial dynamics, elimination and biogenesis during post-ischemic recovery in ischemia-resistant and ischemia-vulnerable gerbil hippocampal regions

M Kawalec, P Wojtyniak, E Bielska, A Lewczuk… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Transient ischemic attacks (TIA) result from a temporary blockage in blood circulation in the
brain. As TIAs cause disabilities and often precede full-scale strokes, the effects of TIA are …

Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4, DG Region?

A Lewczuk, B Zablocka, M Beresewicz-Haller - Molecular Neurobiology, 2023 - Springer
The transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) is the master
regulator of genes known to be involved in antioxidant, and anti-inflammatory processes …

Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients

J Sol, L Colàs-Campàs… - Journal of Cerebral …, 2022 - journals.sagepub.com
Transient ischemic attacks (TIAs) before an acute ischemic stroke (AIS) could induce
ischemic tolerance (IT) phenomena. with an endogenous neuroprotective role (Ischemic …

In Vitro Animal Model for Estimating the Time since Death with Attention to Early Postmortem Stage

M Szeremeta, P Samczuk, K Pietrowska, T Kowalczyk… - Metabolites, 2022 - mdpi.com
Estimating the postmortem interval (PMI) has remained the subject of investigations in
forensic medicine for many years. Every kind of death results in changes in metabolites in …

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

SJ Wang, BR Liu, F Zhang, XR Su, YP Li, CT Yang… - Scientific Reports, 2023 - nature.com
This study differentiates myocardial infarction (MI) and strangulation death (STR) from the
perspective of amino acid metabolism. In this study, MI mice model via subcutaneous …

[PDF][PDF] Physio-pharmacological potentials of taurine: a review in animal and human studies

OM Obukohwo - Asian J. Biol. Sci, 2023 - ajbs.scione.com
Taurine, a sulfur-containing non-protein amino acid is one of the most prevalent amino acids
in all mammalian plasma and tissues. The objective is to identify the therapeutic role of …

Tat-CCT2 Protects the Neurons from Ischemic Damage by Reducing Oxidative Stress and Activating Autophagic Removal of Damaged Protein in the Gerbil …

HJ Kwon, HJ Jeon, GM Choi, IK Hwang, DW Kim… - Neurochemical …, 2023 - Springer
CCT2 is a eukaryotic chaperonin TCP-1 ring complex subunit that mediates protein folding,
autophagosome incorporation, and protein aggregation. In this study, we investigated the …