In higher eukaryotes, enhancers determine the activation of developmental gene
transcription in specific cell types and stages of embryogenesis. Enhancers transform the …

Our understanding of how genomic DNA is tightly packed inside the nucleus, yet is still
accessible for vital cellular processes, has grown dramatically over recent years with …

Prediction of cell type-specific, in vivo transcription factor binding sites is one of the central
challenges in regulatory genomics. Here, we present our approach that earned a shared first …

Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls
produced a comprehensive dataset of the variations causing susceptibility to systemic lupus …

The transcription factor ZNF143 contains a central domain of seven zinc fingers in a tandem
array and is involved in 3D genome construction. However, the mechanism by which …

Transcription factors bind to sequence motifs and act as activators or repressors.
Transcription factors interface with a constellation of accessory cofactors to regulate distinct …

Motivation Genome-wide association studies have revealed that 88% of disease-associated
single-nucleotide polymorphisms (SNPs) reside in noncoding regions. However, noncoding …

Interactions between distal loci, including those involving enhancers and promoters, are a
central mechanism of gene regulation in mammals, yet the protein regulators of these …

Chromatin interactions between cis-regulatory elements (CREs) and specific gene
promoters offer insights into the mechanisms of gene activation and repression. This …

Pairs of interacting transcription factors (TFs) have previously been shown to bind to
enhancers and promoters and contribute to their physical interactions. However, to date, we …