Novel proteomics platforms, such as the aptamer‐based SOMAscan platform, can quantify
large numbers of proteins efficiently and cost‐effectively and are rapidly growing in …

Background: Plasma proteins are critical mediators of cardiovascular processes and are the
targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma …

Despite the dramatic underrepresentation of non-European populations in human genetics
studies, researchers continue to exclude participants of non-European ancestry, as well as …

Abstract Purpose of Review The burden of cardiometabolic diseases such as cardiovascular
disease (CVD) and type 2 diabetes (T2D) is pronounced among African Americans …

Background Glycocalyx shedding and subsequent endothelial dysfunction occur in many
conditions, such as in sepsis, in critical illness, and during major surgery such as in coronary …

Background Recent data indicate a decline in overall longevity in the United States. Even
prior to the COVID‐19 pandemic, an increase in midlife mortality rates had been reported …

Objective: Mexican Americans are disproportionally affected by non-alcoholic fatty liver
disease (NAFLD), liver fibrosis and hepatocellular carcinoma. Noninvasive means to identify …

Background: suPAR (Soluble urokinase plasminogen activator receptor) has emerged as an
important biomarker of coagulation, inflammation, and cardiovascular disease (CVD) risk …

Blood group antigens are inherited traits that may play a role in immune and inflammatory
processes. We investigated associations between blood groups and circulating …

Inflammation biomarkers can provide valuable insight into the role of inflammatory
processes in many diseases and conditions. Sequencing based analyses of such …