Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical
manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal …

Diabetic kidney disease (DKD) accounts for a large proportion of end-stage renal diseases
that require renal replacement therapies including dialysis and transplantation. Therefore, it …

Glucose-induced reactive oxygen species (ROS) production initiates podocyte apoptosis,
which represents a novel early mechanism leading to diabetic nephropathy (DN). Here, we …

Background: Endoplasmic reticulum (ER) stress-induced podocyte apoptosis plays a critical
role in the development of diabetic nephropathy (DN). Here, we tested the hypothesis that …

Background The leading cause of end-stage renal disease (ESRD) is diabetic nephropathy
(DN). Podocyte damage is an early event in the development of DN. Currently, there is no …

The children of obese mothers are known to have a high risk of obesity and metabolic
disease and are prone to developing cognitive deficits, although the underlying mechanism …

Diabetic kidney disease is the leading cause of end-stage renal disease. Podocytes are
differentiated cells necessary for the development and maintenance of the glomerular …

The strong predictive value of proteinuria in chronic glomerulopathies is firmly established
as well as the pathogenic role of angiotensin II promoting progression of glomerular disease …

Diabetic nephropathy is the principal cause of end-stage renal failure and current
interventions for its recession remains unsatisfactory. Mesenchymal stem cells (MSCs) hold …

The current studies used genetic fate mapping to prove that adult podocytes can be partially
replenished following depletion. Inducible NPHS2-rtTA/tetO-Cre/RS-ZsGreen-R reporter …