NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

This review article intends to provide insightful advice for dissolution-dynamic nuclear
polarization in the form of a practical handbook. The goal is to aid research groups to …

Thanks to recent improvements in NMR spectrometer hardware and pulse sequence design,
modern 13C NMR has become a useful tool for biomolecular applications. The complete …

Dissolution dynamic nuclear polarization (d-DNP) is a versatile method to enhance nuclear
magnetic resonance (NMR) spectroscopy. It boosts signal intensities by four to five orders of …

Hyperpolarization has become a powerful tool to enhance the sensitivity of magnetic
resonance. A universal tool to hyperpolarize small molecules in solution, however, has not …

Nuclear magnetic resonance (NMR) spectroscopy is a key method for determining the
structural dynamics of proteins in their native solution state. However, the low sensitivity of …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful method to study the
molecular structure and dynamics of materials. The inherently low sensitivity of NMR …

Elucidation of small molecule–protein interactions provides essential information for
understanding biological processes such as cellular signaling, as well as for rational drug …

Abstract Structure determination lies at the heart of many biochemical research programs.
However, the “giants”: X‐ray diffraction, electron microscopy, molecular dynamics …

Hyperpolarized water can be a valuable aid in protein NMR, leading to amide group 1H
polarizations that are orders of magnitude larger than their thermal counterparts. Suitable …