A growing solid tumor relies on a developing vasculature to meet its needs in terms of
oxygen, nutrients, depuration, etc. This implies that if the vascular bed that has developed …

Tubulin protein is a major target for anticancer drug discovery. As a result, antimitotic agents
constitute an important class of the current anticancer drugs. Hundreds of tubulin inhibitors …

BPR0L075 is a novel synthetic compound discovered through research to identify new
microtubule inhibitors. BPR0L075 inhibits tubulin polymerization through binding to the …

The new arylthioindole (ATI) derivatives 10, 14− 18, and 21− 24, which bear a halogen atom
or a small size ether group at position 5 of the indole moiety, were compared with the …

Agents that interfere with tubulin function have a broad anti-tumor spectrum and they
represent one of the most significant classes of anticancer agents. In the past few years …

This work reports a cost-effective and sustainable protocol for the carbonylative Suzuki–
Miyaura cross-coupling reaction catalyzed by palladium nanoparticles (Pd NPs) supported …

A new series of 2-amino-6-(2-alkyl or arylidenehydrazinyl)-4-(dialkylamino) pyrimidine-5-
carbonitriles, 5–24, were synthesized in satisfactory overall yield, using 2-amino-4 …

The synthesis and study of the structure− activity relationships of two new classes of
synthetic antitubulin compounds based on 1-aroylindole and 3-aroylindole skeletons are …

In this work, synthesis, and crystal structure of molecule 2-amino-4′-fluorobenzophenone
(FAB) is confirmed by using FT-IR, FT-Raman, 1 H and 13 C NMR chemical shifts, compared …

Cornbretastatin A-4 (CA-4) is one of the most potent antinnitotic and antiangiogenic agents
of natural origin. It has displayed potent antitunnor effect in a wide variety of preclinical …