Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery

M Maeki, S Uno, A Niwa, Y Okada, M Tokeshi - Journal of Controlled …, 2022 - Elsevier
In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …

Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation

S Gimondi, H Ferreira, RL Reis, NM Neves - ACS nano, 2023 - ACS Publications
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges

EA Taha, J Lee, A Hotta - Journal of Controlled Release, 2022 - Elsevier
The discovery of clustered regularly interspaced short palindromic repeats (CRISPR)
genome editing technology opened the door to provide a versatile approach for treating …

Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines

T Nakamura, Y Sato, Y Yamada… - Advanced drug delivery …, 2022 - Elsevier
A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …

Intelligent control of nanoparticle synthesis on microfluidic chips with machine learning

X Chen, H Lv - NPG Asia Materials, 2022 - nature.com
Nanoparticles play irreplaceable roles in optoelectronic sensing, medical therapy, material
science, and chemistry due to their unique properties. There are many synthetic pathways …

Engineered CRISPR-Cas systems for the detection and control of antibiotic-resistant infections

Y Wu, D Battalapalli, MJ Hakeem, V Selamneni… - Journal of …, 2021 - Springer
Antibiotic resistance is spreading rapidly around the world and seriously impeding efforts to
control microbial infections. Although nucleic acid testing is widely deployed for the …

Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy

M Chehelgerdi, M Chehelgerdi… - Molecular cancer, 2024 - Springer
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Advanced nanotheranostics of CRISPR/Cas for viral hepatitis and hepatocellular carcinoma

H Kong, E Ju, K Yi, W Xu, YH Lao, D Cheng… - Advanced …, 2021 - Wiley Online Library
Liver disease, particularly viral hepatitis and hepatocellular carcinoma (HCC), is a global
healthcare burden and leads to more than 2 million deaths per year worldwide. Despite …

CRISPR/Cas9 genome editing for tissue‐specific in vivo targeting: nanomaterials and translational perspective

DK Sahel, LK Vora, A Saraswat, S Sharma… - Advanced …, 2023 - Wiley Online Library
Clustered randomly interspaced short palindromic repeats (CRISPRs) and its associated
endonuclease protein, ie, Cas9, have been discovered as an immune system in bacteria …

On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device

K Okuda, Y Sato, K Iwakawa, K Sasaki, N Okabe… - Journal of controlled …, 2022 - Elsevier
The use of lipid nanoparticles (LNPs) for nucleic acid delivery is now becoming a promising
strategy with a number of clinical trials as vaccines or as novel therapies against a variety of …