The challenges of using NAD+-dependent formate dehydrogenases for CO2 conversion

S Alpdağtaş, O Turunen, J Valjakka… - Critical Reviews in …, 2022 - Taylor & Francis
In recent years, CO2 reduction and utilization have been proposed as an innovative solution
for global warming and the ever-growing energy and raw material demands. In contrast to …

Sustainable production of formic acid from CO2 by a novel immobilized mutant formate dehydrogenase

A Tülek, E Günay, B Servili, S Essiz, B Binay… - Separation and …, 2023 - Elsevier
Formate dehydrogenase (NAD+-dependent FDH) is an enzyme that catalyzes the reversible
oxidation of formate to CO 2 while reducing NAD+ to NADH. The enzyme has been used in …

[HTML][HTML] RM1 semiempirical model: chemistry, pharmaceutical research, molecular biology and materials science

NBD Lima, GB Rocha, RO Freire… - Journal of the Brazilian …, 2019 - SciELO Brasil
In this review, we show improvements to the semiempirical quantum chemical method RM1
and present a wide range of its applications as reported by researchers of various areas …

Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii

Q Guo, L Gakhar, K Wickersham, K Francis… - Biochemistry, 2016 - ACS Publications
The structure of formate dehydrogenase from Candida boidinii (CbFDH) is of both academic
and practical interests. First, this enzyme represents a unique model system for studies on …

Engineered formate dehydrogenase from Chaetomium thermophilum, a promising enzymatic solution for biotechnical CO2 fixation

MM Çakar, J Ruupunen, J Mangas-Sanchez… - Biotechnology …, 2020 - Springer
Abstract Objectives Formate dehydrogenases (FDHs) are NAD (P) H-dependent enzymes
that catalyse the reversible oxidation of formate to CO 2. The main goal was to use directed …

Carbon dioxide utilisation—the formate route

LB Maia, I Moura, JJG Moura - Enzymes for solving humankind's problems, 2021 - Springer
The relentless rise of atmospheric CO 2 is causing large and unpredictable impacts on the
Earth climate, due to the CO 2 significant greenhouse effect, besides being responsible for …

Unlocking Catalytic Diversity of a Formate Dehydrogenase: Formamide Activity for NADPH Regeneration and Amine Supply for Asymmetric Reductive Amination

A Maier, T Knaus, FG Mutti, D Tischler - ACS Catalysis, 2024 - ACS Publications
The formate dehydrogenase (FDH) from Candida boidinii is a well-studied and applied
enzyme for NADH regeneration in various reactions. As many oxidoreductases require …

Functional effects of active site mutations in NAD+-dependent formate dehydrogenases on transformation of hydrogen carbonate to formate

U Pala, B Yelmazer, M Çorbacıoğlu… - Protein Engineering …, 2018 - academic.oup.com
Conversion of hydrogen carbonate to formate by mutants of Candida methylica (Cm FDH)
and Chaetomium thermophilum (Ct FDH) formate dehydrogenases (FDHs) was studied …

Tailoring of recombinant FDH: effect of histidine tag location on solubility and catalytic properties of Chaetomium thermophilum formate dehydrogenase (CtFDH)

H Esen, S Alpdağtaş, M Mervan Çakar… - Preparative …, 2019 - Taylor & Francis
Several protein expression systems can be used to get enzymes in required quantities and
study their functions. Incorporating a polyhistidine tag is a beneficial way of getting various …

Identification of catalysis, substrate, and coenzyme binding sites and improvement catalytic efficiency of formate dehydrogenase from Candida boidinii

W Jiang, P Lin, R Yang, B Fang - Applied Microbiology and Biotechnology, 2016 - Springer
Formate dehydrogenases (FDHs) are continually used for the cofactor regeneration in
biocatalysis and biotransformation with hiring NAD (P) H-dependent oxidoreductases. Major …